I'm the new agent, and I'm invigorated by some of the amazing books I've rescued from the slushpile. But there's a lot of things I'd like to see that I'm not. Some specifics:
Mormon historical novels. This is a rich and deep vein that hasn't been explored. I'd love to see a well-written book about Zina Huntington, a secret wife to Joseph Smith and faith healer, in the vein of Orson Scott Card's Saints.
Crusades historical or fantastorical novels in the vein of George R.R. Martin, Jacqueline Carey or Bernard Cornwell. Give me blood-drenched battles, intricate politics, good old steamy sex and bring the religious frontiers of the medieval Mediterranean into it.
Victorian, Edwardian, or Regency fantasy. Given the massive success of this genre lately, I'm surprised at how little we see it in the slushpile. If you have the next Jonathon Strange and Mr. Norrell, send me an email.
These are all genres where I'd accept the breaking of the traditional "word ceiling" for new authors, usually set around 100-120,000 words. Historical and fantasy novels need to be long and absorbing, and some new authors can pull it off. For shorter works, I'm always in the mood for a good memoir, particularly if it can deal with painful events through a good sense of humor. I also love Chuck Palahniuk and Dave Eggers, so if you can do literary satire, drop a note.
You can reach Spencer at firstname.lastname@example.org